Rabeprazole sodium belongs to the category of medication known as proton pump inhibitors. It reduces the manufacturing of abdomen acid and protects in opposition to acidity and gastric ulcers. Rabeprazole helps relieve signs akin to heartburn, acidic breath, and issue swallowing. It helps forestall harm to the gastric mucosa.
Rabeprazole sodium is offered each as pill and capsule types. The capsule type is a slow-release formulation, i.e, the remedy is launched slowly in your physique and takes time to indicate full impact.
Rabeprazole sodium is offered with the model title, Aciphex. Additionally it is out there as a generic drug. A generic drug prices lower than the brand-name model.
Model title of Rabeprazole Sodium
Formulations out there
- Pill (10 mg and 20 mg)
- Capsule (slow-release)
Lively ingredient: Rabeprazole sodium
Inactive ingredient: Mannitol, magnesium oxide, hydroxypropyl cellulose, magnesium stearate, hydroxypropyl methylcellulose phthalate, ethylcellulose, iron oxide yellow (coloring agent), titanium oxide, talc, low-substitutedhydroxypropyl cellulose, carnauba wax, diacetylatedmonoglycerides
Makes use of of Rabeprazole Sodium pill
Its makes use of embody:
1. Gastric ulcers
Gastric ulcers consult with the soreness within the abdomen. The abdomen mucosa erodes because of the elevated acid manufacturing within the abdomen. Rabeprazole sodium is used to deal with all sorts of gastric and peptic ulcers by reducing the manufacturing of gastric acid.
2. Duodenal ulcers
Duodenal ulcers develop within the duodenum that’s the first a part of the small gut. It happens on account of erosion of the intestinal lining by the elevated quantity of acid.
3. Gastric Esophageal Reflux Illness (GERD)
GERD is a illness through which elevated abdomen acid manufacturing ends in regurgitation of the abdomen acid into the esophagus. This causes a burning sensation within the decrease finish of the esophagus and alongside all the size of the esophagus in extreme instances. Regurgitation happens as a result of the decrease esophageal sphincter (LES) could also be broken or weakened. Signs akin to a bitter style within the mouth and burping can be current.
3. Most cancers of esophagus
An excessive amount of acid within the abdomen may cause acid regurgitation into the esophagus. This damages the epithelial lining of the esophagus and will increase the chance of most cancers.
4. Zollinger-Ellison syndrome
It is a uncommon situation that causes elevated abdomen acid manufacturing from a neuroendocrine tumor, known as gastrinoma. This ends in peptic ulcers.Rabeprazole sodium will help deal with this situation.
5. Helicobacter Pylori Infections
It may be taken as a mix remedy to deal with sure infections akin to H. Pylori infections. On this case, docs prescribe rabeprazole sodium together with two antibiotics; amoxicillin and clarithromycin.
6. Erosive esophagitis
Erosive esophagitis can happen on account of harm to your esophagus on account of abdomen acid regurgitation.Rabeprazole sodium will help forestall erosion of the esophagus.
Elevated acid manufacturing within the abdomen is a reason for all these situations.
Dosage of Rabeprazole Sodium
It’s best to take rabeprazole sodium earlier than meals. In case your physician prescribes you to take it two instances a day, take one pill within the morning and one pill within the night.
Take 20 mg pill as soon as each day. The utmost period for utilization is 4 to eight weeks.
For kids (above 18 years of age)
Take 20 mg pill as soon as each day. The utmost period for utilization is as much as 8 weeks.
Within the case of Zollinger- Ellison syndrome
The dosage must be elevated to 60 mg as soon as each day in Zollinger-Ellison syndrome. The utmost dosage will be 100 mg as soon as each day or 60 mg twice each day.
- Aciphex Sprinkle will be given to youngsters beneath 12 years of age. It’s a protected formulation developed for protected use in youngsters.
Distribution in Plasma
Rabeprazole sodium is 97% certain to plasma proteins.
The shelf lifetime of rabeprazole sodium is 2 years.
The half-life of rabeprazole is 1 hour, i.e., 50% of the drug is eradicated from the physique in a single hour.
The bioavailability of rabeprazole sodium is 52%. Because of this this proportion of the administered drug reaches the systemic circulation or bloodstream.
How does Rabeprazole sodium work?
Rabeprazole sodium is an anti-secretory remedy. It first will get absorbed by the parietal cells current within the mucosal lining of the abdomen. Chemical reactions within the parietal cells activate the drug. It really works by reducing the manufacturing of abdomen acid. It inhibits the hydrogen-potassium ATPase pump within the abdomen lining, thereby reducing hydrogen ions launch into the abdomen lumen. Consequently, the manufacturing of abdomen acid is decreased.
Instructions to make use of Rabeprazole sodium
Learn the leaflet completely that comes with the remedy earlier than you begin taking rabeprazole sodium tablets. In case of any queries, seek the advice of your physician or pharmacist.
Rabeprazole sodium tablets
Take the tabletwith or with out meals or as prescribed by your doctor. Eat it 1 to 2 instances a day. Swallow the pill as a complete and don’t crush, chew or break it. Crushing, chewing, or breaking the pill can launch the contents without delay. Consequently, the chance of unwanted side effects will increase.
Rabeprazole sodium capsules
If you’re utilizing rabeprazole sodium capsules, take them half-hour earlier than your foremost meal of the day or as directed by your doctor. Break open the capsule and sprinkle in your meals or any liquid preparation. You may as well use the remedy with apple juice or toddler method (when utilizing in youngsters). Preserve the temperature of your meals or liquid preparation at or under room temperature. Eat it as quickly as potential, inside quarter-hour. Don’t swallow the capsule as a complete.
Take it frequently at a set time that will help you keep in mind in order that you don’t miss a dose.
Negative effects of Rabeprazole sodium
Frequent unwanted side effects embody:
- Abdomen disturbances
- Nausea and vomiting
- Diarrhea (It may be attributable to Clostridium difficile an infection. Inform your physician for those who discover blood in stool or mucus in stool.)
- Issues in digestion
- Electrolyte disturbances akin to magnesium deficiency (indicators of magnesium deficiency embody tremors, irregular heartbeat, and muscle aches)
- A lupus-like syndrome (signs embody a rash on the face or cheeks and joint ache)
Some uncommon unwanted side effects of this remedy embody:
- Vitamin B12 deficiency (Signs embody muscle weak spot, numbness, tingling in palms and ft, and sore tongue. Rabeprazole sodium decreases the absorption of vitamin B12 within the gastrointestinal tract. If in case you have been taking rabeprazole sodium for a protracted interval, seek the advice of your physician whether or not you must begin vitamin B12 dietary supplements together with the remedy.)
- Allergic response to the product (characterised by swelling, redness, and rash)
- Problem in respiratory
- Extreme dizziness
- Dry mouth
- Weight achieve
- Kidney issues (signs embody ache in urination, fever, swollen ft, and decrease again ache)
- Superinfection of Clostridium difficile micro organism
- Rabeprazole sodium can enhance the chance of bone weak spot and bone fractures if taken for an prolonged interval (can lead to an elevated incidence of fractures of the wrist, hip, or backbone)
- Encephalopathy (mind swelling)
- Acute interstitial nephritis
- Darkish-colored urine
- Stevens- Johnsons syndrome
Milder unwanted side effects go away in a number of days to a few weeks. If the unwanted side effects don’t go away or develop into extra extreme after rabeprazole sodium use, inform your physician as quickly as potential. Sufferers on long-term therapy must be stored beneath strict supervision to verify for vitamin B12, vitamin D, and calcium values within the blood.
The way to handle unwanted side effects of Rabeprazole Sodium:
Guarantee a lot consumption of water and take correct relaxation. Seek the advice of your doctor to prescribe you a painkiller if the headache is extreme. Your headache ought to go away inside every week of taking rabeprazole. If it persists, contact your physician.
Drink loads of water to keep away from dehydration. Don’t take an antiemetic with out consulting your physician. Keep away from consuming spicy meals.
Drink loads of water to keep away from dehydration. Indicators of dehydration embody strong-smelling urine or decreased quantity of urine. Don’t take anti-diarrheal medicines with out consulting your physician.
Keep away from consuming these meals that trigger gasoline akin to beans or lentils. Eat small meals; eat extra often somewhat than consuming larger meals. Simethicone, out there on the pharmacy, will help as effectively.
In case you develop constipation, enhance the quantity of fiber in your weight-reduction plan. Eat extra contemporary greens, fruits, and cereals. Guarantee a lot consumption of water and train frequently. If signs don’t enhance, verify together with your physician.
For those who expertise weight achieve whereas taking rabeprazole sodium, seek the advice of your physician. Don’t preserve a sedentary way of life and train frequently. Nonetheless, don’t skip meals to drop a few pounds.
- For those who use rabeprazole sodium for an prolonged interval, get your vitamin B12 ranges checked within the laboratory frequently.
- Hold it away from the attain of kids and pets.
- Eliminate the drugs correctly and don’t flush it down the bathroom.
- Don’t use it after the expiry date.
- It’s not protected to make use of rabeprazole sodium tablets in sufferers beneath 12 years of age and rabeprazole sodium capsules in youngsters youthful than one 12 months.
- Don’t eat greater than the really helpful dose.
- Eat loads of water whereas taking the remedy.
- Keep away from utilizing the remedy if the packaging is torn or the seal is damaged.
- Don’t use rabeprazole sodium to deal with every other situation apart from that suggested by the physician. If in case you have any queries, focus on them together with your doctor.
- For those who take the remedy out of its authentic packing or container, it can’t be saved correctly. So hold it in its authentic container for correct storage.
- Don’t hold it in moist situations akin to within the washroom or on the sink. Moisture can destroy the remedy.
Contraindications to be used of rabeprazole sodium
Inform your physician or pharmacist for those who endure from the next situations:
If you’re a affected person of liver illness or hepatitis, your liver wouldn’t be wholesome sufficient to clear the drug out of your physique. Consequently, rabeprazole sodium ranges enhance within the physique which will be dangerous. It may well additionally enhance the severity of unwanted side effects. For those who endure from liver illness, seek the advice of your physician earlier than beginning this remedy.
Lupus is an autoimmune dysfunction. Rabeprazole can worsen the signs of lupus. It may well additionally trigger new signs to happen. That’s the reason rabeprazole is contraindicated on this situation.
Allergic response to the remedy
Don’t use the remedy once more in case you are a identified allergic to the drug. Taking the remedy once more will be life-threatening.
Allergic reactions to comparable medication akin to lansoprazole or omeprazole
If you’re allergic to proton pump inhibitors (PPIs), don’t use this remedy. Seek the advice of your physician earlier than utilizing. Your physician can prescribe you an alternative choice to this remedy akin to Gaviscon.
Calcium or Vitamin D deficiency
If you’re affected by calcium or vitamin D deficiency, don’t use rabeprazole sodium. Seek the advice of your doctor earlier than beginning the remedy.
If you’re pregnant or planning a being pregnant
This remedy can solely be used when vital. Though there’s a restricted examine out there concerning the dangerous results of rabeprazole on people, it’s unsafe to make use of in being pregnant. At all times seek the advice of your physician earlier than beginning with the remedy throughout being pregnant.
No proof is recorded whether or not this remedy passes into the breast milk but it surely must be used with warning. Nonetheless, the proton pump inhibitor known as omeprazole is comparatively protected in lactating moms.
Rabeprazole can worsen osteoporosis and bone weak spot. So it’s not really helpful in sufferers with osteoporosis. Docs advise utilizing this medication together with vitamin D dietary supplements.
Youngsters beneath 12 years of age
There isn’t a medical proof whether or not rabeprazole sodium is protected to make use of in youngsters or not. Nonetheless, it may be used safely in youngsters above 12 years of age however for a most period of 8 weeks.
If in case you have undergone endoscopy
Don’t begin utilizing this remedy when you have undergone an endoscopy just lately. Inform your physician earlier than beginning rabeprazole sodium.
Interactions of Rabeprazole Sodium with different medication
Earlier than utilizing rabeprazole sodium, inform your physician about all of the prescription and non-prescription medicines you take. Sure medicines can alter the way in which how a drug works. Drug interactions with rabeprazole sodium may cause extreme reactions or enhance the chance of unwanted side effects. Don’t taper the dose or cease the medicines by your self. At all times seek the advice of your physician earlier than beginning or stopping any remedy.
Medicine that may work together with rabeprazole sodium and enhance the chance of unwanted side effects embody:
- Methotrexate (anti-cancer drug; additionally used to deal with psoriasis and rheumatoid arthritis)
- Anti-HIV medication (akin to Atazanavir, saquinavir)
- Blood thinners (akin to warfarin and heparin)
- Clopidogrel (anti-platelet drug)
- Digoxin (a cardiac drug)
- Cyclosporine (a drug used to suppress the immune response in case of organ transplant or tissue grafting)
- Rifampicin (an antibiotic used to deal with tuberculosis)
Medicine that work together with rabeprazole sodium and make it much less efficient embody:
- Azole antifungals (akin to ketoconazole, posaconazole and itraconazole)
- Anti-cancer medication (akin to erlotinib, nilotinib, and dasatinib)
- Mycophenolatemofetil (a drug used to forestall organ transplant rejection)
- Iron dietary supplements
- Antidepressants (akin to fluvoxamine)
Rabeprazole sodium decreases the impact of the next medication:
(Rilpivirine is a non-nucleoside reverse transcriptase inhibitor. it additionally decreases gastric acid manufacturing, reinforcing the impact of rabeprazole. The alkaline pH of the abdomen interferes with the absorption of rilpivirine as it’s effectively absorbed in acidic situations. So each these medication can’t be used concurrently.)
Interplay of Rabeprazole sodium with meals
Rabeprazole sodium doesn’t have any interactions with meals. Your meals might be digested within the regular means however it will possibly delay its absorption for as much as 1.7 hours.
Results of Rabeprazole sodium on Lab experiences
Rabeprazole sodium can even have an effect on sure lab experiences inflicting false-negative exams. Be certain that to inform your physician or laboratory technician that you just use this drug.
Rabeprazole sodium can have an affect on blood cell counts. For instance, it can lead to:
- Leucopenia (decreased white blood cells)
- Neutropenia (decreased neutrophils)
- Thrombocytopenia (lower within the variety of platelets)
Seek the advice of your physician if:
- the situation persists or worsens over time.
- The severity of unwanted side effects enhance
- Extreme and frequent vomiting
- For those who expertise extreme, persistent diarrhea, belly ache, blood in stool, or fever
- Unexplained weight reduction
- Chest and shoulder ache, with shortness of breath
- Seizures or tremors
- Black stools (on account of passing of blood in stool)
- For those who vomit blood (hematemesis)
Overdosage of Rabeprazole Sodium
Contact the physician or poison management middle if somebody has overdosed on rabeprazole sodium tablets. Signs of overdose embody:
- Irregular/ quick heartbeat
- Blurred imaginative and prescient
- Extreme belly ache
An overdose happens as a result of rabeprazole sodium binds to the plasma proteins and is reversible with out medical therapy. Nonetheless, these signs usually are not reported in overdoses as much as 80 mg.
Habit Legal responsibility
Rabeprazole sodium just isn’t a habit-forming drug i.e., it has no abuse potential.
Nonetheless, in case you are utilizing rabeprazole sodium for a protracted interval, seek the advice of your physician earlier than stopping the remedy. Stopping the remedy after taking it for a protracted interval can enhance acid manufacturing within the abdomen and make your signs return.
One other formulation is offered known as rabeprazole-ER (Rabeprazole- Prolonged Launch). It was developed to extend the half-life of rabeprazole. It’s usually too exact in people.
Rabeprazole sodium and domperidone capsules
It is a well-tolerated, mixture remedy used to deal with abdomen acidity, ulcers, and heartburn.
Domperidone capsules enhance the peristaltic motion of the abdomen and intestines to maneuver meals throughout the gastrointestinal tract successfully and rapidly. It’s a prokinetic drug.
It’s suggested to take this mix remedy one hour earlier than a meal, ideally within the morning.
Modifications in weight-reduction plan that may treatment GERD
The weight-reduction plan you eat can have an effect on the quantity of acid produced within the gastrointestinal tract. The listed meals can’t treatment your situation however can deliver an enchancment in your signs:
- Non-citrus fruits
- Lean meat
- Wholesome fat
- Egg white
You must add these meals to your weight-reduction plan along with taking rabeprazole sodium tablets in order that your signs will be improved.
Keep away from the next meals:
- Citrus meals
- Excessive-fat meals
- Garlic and onions
Often requested questions
What’s rabeprazole sodium?
Rabeprazole sodium is a sodium salt of the prodrug rabeprazole, a proton pump inhibitor. It has anti-ulcer exercise and helps treatment GERD and peptic ulcer illness.
What must be the size of therapy with rabeprazole sodium?
The size of therapy with this remedy will depend on your current situation and your physique’s response to the therapy. Your physician will advocate that for the way lengthy the therapy ought to proceed. Some individuals have to take rabeprazole solely when wanted,i.e., when signs present. As soon as the affected person feels higher, he/she will cease taking the remedy.
Can I take antacids together with rabeprazole sodium?
Sure, you may take antacids together with rabeprazole. For those who take sucralfate (antacid), eat sucralfate half-hour earlier than rabeprazole sodium tablets.
Can I cease taking the remedy if I really feel higher?
Proceed taking the remedy for so long as your physician has prescribed it. Don’t cease the remedy beforehand even for those who begin feeling higher. In any other case, the situation can relapse.
Can I take anti-diarrheal medicines if I develop diarrhea after utilizing rabeprazole sodium?
Don’t take anti-diarrheal or opioid medicines for those who expertise any signs of diarrhea or belly ache. These medicines could make the signs worse.
What if I miss a dose?
For those who miss a dose or neglect to take one, eat it as quickly as you keep in mind. If it’s time for the following dose, skip the earlier one. By no means take a double dose at a time. For those who neglect doses usually, set an alarm as a reminder.
How ought to I retailer the remedy?
Bear in mind to retailer rabeprazole sodium tablets in a cool and dry place. Hold it away from moisture and warmth. The temperature must be between 15 to 30 levels Celsius.
What occurs if I take the remedy for an extended interval than prescribed?
Taking the remedy for a very long time may cause extreme unwanted side effects akin to vitamin B12 deficiency and bone fractures. It may well additionally trigger a situation known as fundic gland polyps. So it’s suggested to take rabeprazole sodium for under a brief size of time as prescribed by your physician.
Can taking this remedy for a protracted interval trigger abdomen most cancers?
Sufferers who take rabeprazole sodium for an prolonged interval (for nearly 3 years or extra) can have an opportunity of creating abdomen most cancers. Nonetheless, the possibilities are very low. Medicines like rabeprazole sodium can lead to unwanted side effects so these medicines must be taken for a brief interval.
Is there any various to this remedy?
Options to rabeprazole sodium can be found on the pharmacy. Talk about together with your physician if this remedy doesn’t go well with you or for those who develop any extreme signs. Your physician can prescribe you an alternative choice to this medication. Options can embody omeprazole, esomeprazole, pantoprazole or lansoprazole.
Is it protected to make use of rabeprazole and domperidone mixture?
Sure, it’s protected to make use of this mix remedy. It’s protected for most individuals however can lead to delicate to extreme unwanted side effects in different individuals. Negative effects embody diarrhea, headache, belly ache, and lightheadedness. Inform your doctor for those who expertise any of those signs.
What are the contraindications of rabeprazole and domperidone capsules?
Contraindications of this mix remedy embody allergic reactions to both rabeprazole or domperidone. Allergic reactions can be attributable to every other inactive components within the remedy. Individuals with liver or kidney illness are additionally suggested to make use of the remedy cautiously.
Can I get a refillable prescription for this remedy?
Sure, the prescription for rabeprazole sodium is refillable. You wouldn’t want a brand new prescription for this remedy each time. Your physician will write all the course of remedy or the variety of refillable in your prescription.
Can I carry this remedy with me whereas travelling?
Sure, you may carry rabeprazole sodium tablets with you whereas travelling however don’t put them in your check-in baggage. You possibly can hold it in your hand-carry. At all times carry the physician’s prescription with you to be able to present the airport workers when requested for it.
Which different PPIs can be utilized for GERD?
Omeprazole (Prilosec) and esomeprazole (Nexium) are different PPIs that can be utilized for GERD. Omeprazole and esomeprazole are comparable medication and there’s solely a minor distinction between their chemical construction.
Will the dose of rabeprazole sodium be elevated or decreased?
Your physician might enhance your dose of rabeprazole if he/she feels that your signs aren’t enhancing. Relying in your situation, your physician might advocate you to take the next dose for a month or so. After this, you might have to take a decrease dose.
Which proton pump inhibitor (PPI) is protected to make use of in being pregnant?
Omeprazole is the most secure PPI to make use of in being pregnant. Nonetheless, it’s advisable to deal with the signs of heartburn with weight-reduction plan management and different cures throughout being pregnant. Eat smaller meals and eat extra often. Drink a lot of water. If the signs don’t enhance, seek the advice of your physician to prescribe you omeprazole that will help you.
When will my signs begin to enhance?
Your signs might begin to enhance in 2 to three days of taking rabeprazole sodium. However in some sufferers, it might take longer to enhance the signs of heartburn or peptic ulcer.
Can I take painkillers for belly ache together with rabeprazole sodium?
Sure, it’s protected to take painkillers with rabeprazole sodium for belly ache or different sorts of ache. Painkillers akin to paracetamol and ibuprofen can be utilized.
Can I drink alcohol whereas taking rabeprazole sodium?
No, it’s not protected to drink alcohol whereas taking rabeprazole sodium. Alcohol consumption can enhance the manufacturing of acid within the abdomen. This may irritate the abdomen mucosa and make the signs worse.